The cytoskeleton has a central role in eukaryotic biology, enabling cells to organize internally, polarize, and translocate. Studying cytoskeletal machinery across the tree of life can identify common elements, illuminate fundamental mechanisms, and provide insight into processes specific to less‐characterized organisms. Red algae represent an ancient lineage that is diverse, ecologically significant, and biomedically relevant. Recent genomic analysis shows that red algae have a surprising paucity of cytoskeletal elements, particularly molecular motors. Here, we review the genomic and cell biological evidence (...) and propose testable models of how red algal cells might perform processes including cell motility, cytokinesis, intracellular transport, and secretion, given their reduced cytoskeletons. In addition to enhancing understanding of red algae and lineages that evolved from red algal endosymbioses (e.g., apicomplexan parasites), these ideas may also provide insight into cytoskeletal processes in animal cells. (shrink)

Regulation of microtubule (MT) dynamics is essential for many cellular processes, but the machinery that controls MT dynamics remains poorly understood. MT plus‐end tracking proteins (+TIPs) are a set of MT‐associated proteins that dynamically track growing MT ends and are uniquely positioned to govern MT dynamics. +TIPs associate with each other in a complex array of inter‐ and intra‐molecular interactions known as the “+TIP network.” Why do so many +TIPs bind to other +TIPs? Typical answers include the ideas that these (...) interactions localize proteins where they are needed, deliver proteins to the cortex, and/or create regulatory pathways. We propose an additional and more mechanistic hypothesis: that +TIPs bind each other to create a superstructure that promotes MT assembly by constraining the structural fluctuations of the MT tip, thus acting as a polymerization chaperone. (shrink)

Parental reading to young children is well-established as being positively associated with child cognitive development, particularly their language development. Research indicates that a particular, “intersubjective,” form of using books with children, “Dialogic Book-sharing”, is especially beneficial to infants and pre-school aged children, particularly when using picture books. The work on DBS to date has paid little attention to the theoretical and empirical underpinnings of the approach. Here, we address the question of what processes taking place during DBS confer benefits to (...) child development, and why these processes are beneficial. In a novel integration of evidence, ranging from non-human primate communication through iconic gestures and pointing, archaeological data on Pre-hominid and early human art, to experimental and naturalistic studies of infant attention, cognitive processing, and language, we argue that DBS entails core characteristics that make it a privileged intersubjective space for the promotion of child cognitive and language development. This analysis, together with the findings of DBS intervention studies, provides a powerful intellectual basis for the wide-scale promotion of DBS, especially in disadvantaged populations. (shrink)

In this paper we develop a new methodology for normative theorising, which we call Directed Reflective Equilibrium. Directed Reflective Equilibrium is based on a taxonomy that distinguishes between a number of different functions of hypothetical cases, including two dimensions that we call representation and elicitation. Like its predecessor, Directed Reflective Equilibrium accepts that neither intuitions nor basic principles are immune to revision and that our commitments on various levels of philosophical enquiry should be brought into equilibrium. However, it also offers (...) guidance about how different types of cases ought to be sequenced to achieve this result. We argue that this ‘directional’ approach improves, in various ways, upon the non-directional approach of traditional Reflective Equilibrium. (shrink)

The advent of artificial intelligence (AI) challenges political theorists to think about data ownership and policymakers to regulate the collection and use of public data. AI producers benefit from free public data for training their systems while retaining the profits. We argue against the view that the use of public data must be free. The proponents of unconstrained use point out that consuming data does not diminish its quality and that information is in ample supply. Therefore, they suggest, publicly available (...) data should be free. We present two objections. First, allowing free data use promotes unwanted inequality. Second, contributors of information did not and could not anticipate that their contribution would be used to train AI systems. Therefore, charging for extensive data use is pro tanto permissible and desirable. We discuss policy implications and propose a progressive data use tax to counter the inequality arising. (shrink)

We use the U.S. Supreme Court’s decision in Citizens United v. Federal Election Commission to assess the reputational risks created by political investment opportunities that allow managers to spend unlimited and potentially undisclosed firm resources on independent political expenditures. This new opportunity raises important ethical questions, as it is difficult, and perhaps impossible, under current law for shareholders to hold managers accountable for this investment choice and the reputational risks it entails. Using firms’ known political activity as a proxy for (...) managers’ likely future use of independent political expenditures, we examine how market participants reacted to Citizens United, conditional on this prior activity and corporate governance attributes related to the concentration of decision rights in senior management and blockholders. The results of our analyses document that firms with both a high level of known political activity and CEO-chairperson of the board duality experienced negative abnormal returns in reaction to Citizens United. In contrast, firms with concentrated ownership experienced positive abnormal returns; however, as known political activity increased, investors discounted the benefits of concentrated ownership. These findings suggest that investors expect this expansion of firms’ political investment opportunities to amplify principal-agent problems inherent in corporate political activity. Additionally, our findings provide evidence for those deliberating the mandatory disclosure of firms’ investments in politics as a means of increasing managerial accountability to both shareholders and the public. (shrink)

Open peer commentary on the article “Examining the Role of Re-Presentation in Mathematical Problem Solving: An Application of Ernst von Glasersfeld’s Conceptual Analysis” by Victor V. Cifarelli & Volkan Sevim. Upshot: Cifarelli and Sevim discuss the development of individual students’ abstract conceptual structures while problem solving, using constructs for analysis that are consistent with von Glasersfeld’s radical constructivism: re-presentation and reflective abstraction. This commentary discusses the on-going contributions of reflective abstraction to individual and collective learning.

We present a canonical form for definable subsets of algebraically closed valued fields by means of decompositions into sets of a simple form, and do the same for definable subsets of real closed valued fields. Both cases involve discs, forming "Swiss cheeses" in the algebraically closed case, and cuts in the real closed case. As a step in the development, we give a proof for the fact that in "most" valued fields F, if f(x),g(x) ∈ F[ x] and v is (...) the valuation map, then the set {x : v(f(x)) ≤ v(g(x))} is a Boolean combination of discs; in fact, it is a finite union of Swiss cheeses. The development also depends on the introduction of "valued trees", which we define formally. (shrink)

In most U.S. jurisdictions, clinicians providing informal “curbside” consults are protected from medical malpractice liability due to the absence of a doctor-patient relationship. A recent Minnesota Supreme Court case, Warren v. Dinter, offers the opportunity to reassess whether the majority rule is truly serving the best interests of patients.

High levels of alexithymia are typically associated with impaired memory for emotional, but not neutral words. We conducted two experimental studies to establish if this effect generalises to non-v...

In their paper, “Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Diseases?” Holly Fernandez Lynch and colleagues have present...

The contributors represent the complete spectrum of positions between a relativism that challenges the very concept of a single world and the idea that there are ascertainable, objective universals.

Economics is probably the most subtle, precise and powerful of the social sciences and its theories have deep philosophical import. Yet the dominant alliance between economics and philosophy has long been cheerfully simple. This is the textbook alliance of neo-Classicism and Positivism, so crucial to the defence of orthodox economics against by now familiar objections. This is an unusual book and a deliberately controversial one. The authors cast doubt on assumptions which neo-Classicists often find too obvious to defend or, indeed, (...) to mention. They set out to disturb an influential concensus and to champion an unpopular cause. Although they go deeper into both philosophy and economics than is usual in interdisciplinary works, they start from first principles and the text is provokingly clear. This will be a stimulating book for all economic theorists and philosophers interested in the philosophy of science and social science. (shrink)

The philosophical concept of analogy is fundamental to the theory of imaging that characterizes Plato’s metaphysics, cosmology, and methodology. While Plato never explicitly conceptualizes the philosophical role of analogy, his dialogues are rife with analogies and images that are often pivotal to the thought expressed there. An analysis of celebrated analogies such as the sun and the good in the Republic, the “second sailing” in the Phaedo, the “receptacle” (chōra) in the Timaeus, and the example of weaving in the Statesman (...) reveals that even if the theory each elucidates is not explicitly concerned with analogy, the theories these images enable are structured by analogy. Thus, although there is no theory of analogy in Plato’s dialogues, the dialogues’ theory is itself analogical. Given this, the broader philosophical point that any account of reflection will have recourse to the structure of analogy because of the unique capacity of the analogical form to reflect the nature of similarity without occluding difference, something a mere likeness is unable to accomplish. It is concluded, therefore, that i) in its thinking, rather than merely in its expression, Plato’s philosophy is analogical and ii) analogy is key to philosophy’s self-reflection. (shrink)

Although Socrates’ use of induction and epagogic argumentation in Plato’s dialogues is well studied, scholarship on Platonic methodology lacks a clear account of Plato’s own view of epagōgē. In this paper, I refute Richard Robinson’s claim that Plato had no awareness of epagōgē, arguing that the “method of collection” serves as Plato’s theory of dialectical induction. Using the evidence of both the Statesman and the Sophist, I maintain that the abstraction characteristic of collection may be ‘purified’ of its empirical origins (...) in its dialectical application to the inquiry into forms. In addition to providing a unifying thread from Socratic to Platonic and, finally, Aristotelian epagōgē, this view also offers evidence for the consistency of dialectical methodology within the dialogues. (shrink)

In his recent book Bad Beliefs and Why They Happen to Good People, Neil Levy argues that conspiracy theories result from the same rational processes that underlie epistemic success. While we think many of Levy’s points are valuable, like his criticism of the myth of individual cognition and his emphasis on the importance of one’s social epistemic environment, we believe that his account overlooks some important aspects. We argue that social deference is an active process, and as such can be (...) helped or hindered by epistemic virtues and vices. With this in mind, holders of bad beliefs acquire more responsibility than is considered by Levy. (shrink)

Twentieth century philosophers introduced the distinction between “objective rightness” and “subjective rightness” to achieve two primary goals. The first goal is to reduce the paradoxical tension between our judgments of what is best for an agent to do in light of the actual circumstances in which she acts and what is wisest for her to do in light of her mistaken or uncertain beliefs about her circumstances. The second goal is to provide moral guidance to an agent who may be (...) uncertain about the circumstances in which she acts, and hence is unable to use her standard moral principle directly in deciding what to do. This paper distinguishes two important senses of “moral guidance”; proposes criteria of adequacy for accounts of subjective rightness; canvasses existing definitions for “subjective rightness”; finds them all deficient; and proposes a new and more successful account. It argues that each comprehensive moral theory must include multiple principles of subjective rightness to address the epistemic situations of the full range of moral decision-makers, and shows that accounts of subjective rightness formulated in terms of what it would reasonable for the agent to believe cannot provide that guidance. (shrink)

Recently two distinct forms of rule-utilitarianism have been introduced that differ on how to measure the consequences of rules. Brad Hooker advocates fixed-rate rule-utilitarianism, while Michael Ridge advocates variable-rate rule-utilitarianism. I argue that both of these are inferior to a new proposal, optimum-rate rule-utilitarianism. According to optimum-rate rule-utilitarianism, an ideal code is the code whose optimum acceptance level is no lower than that of any alternative code. I then argue that all three forms of rule-utilitarianism fall prey to two fatal (...) problems that leave us without any viable form of rule-utilitarianism. (shrink)

In this book, the author is attempting to make sense, as a philosopher, of the ideas of rationality put forward by economists, sociologists, and political theorists. The book intervenes in intense current debates within and among several disciplines. Its concern is with the true nature of social actors and the proper character of social science. Its arguments are the more challenging for being presented in simple, incisive, and lucid prose.

Although justice is a central principle in clinical ethics, work that centers social justice is often marginalized in clinical ethics. In addition to institutional barriers that may be preventing clinical ethicists from becoming the activists that Meyers argues we should be, we must also recognize the barriers embedded in the field of clinical ethics itself. As clinical ethicists, we have an opportunity to support anti‐racism work in particular by altering our own organizational structures to be more inclusive and reflective of (...) the Black, Indigenous, and other communities of color we serve, enhancing clinical ethics education and training by making critical theories foundational, and decolonizing our clinical ethics consultation tools and practices. (shrink)

Background In end-of-life situations, the phrase “do everything” is sometimes invoked by physicians, patients, or substitute decision-makers, though its meaning is ambiguous. We examined instances of the phrase “do everything” in the archive of the Ontario Consent and Capacity Board in Canada, a tribunal with judicial authority to adjudicate physician–patient conflicts in order to explore its potential meanings. Methods We systematically searched the CCB’s online public archive from its inception to 2018 for any references to “do everything” in the context (...) of critical care medicine and end-of-life care. Two independent assessors reviewed decisions, collected characteristics, and identified key themes. Results Of 598 cases in the archive, 41 referred to “do everything” in end-of-life situations. The phrase was overwhelmingly invoked by SDMs, typically to advocate for life-prolonging measures that contradicted physician advice. Physicians generally related “doing everything” to describe the interventions they had already performed, using it to recommend focusing on patients’ quality of life. SDMs were generally reluctant to accept death, whereas physicians found prolonging life at all costs to be morally distressing. The CCB did not interpret appeals to “do everything” legally but followed existing laws by deferring to patients’ prior wishes whenever known, or to concepts of “best interests” when not. The CCB generally recommended against life-prolonging measures in these cases, focusing on patients’ “well-being” and “best interests.” Conclusions In this unique sample of cases involving conflict surrounding resuscitation and end-of-life care, references to “do everything” highlighted conflicts over quantity versus quality of life. These appeals were associated with signs of cognitive distress on the behalf of SDMs who were facing the prospect of a patient’s death, whereas physicians identified moral distress related to the prolongation of patients’ suffering through their use of life-sustaining interventions. This divergence in perspectives on death versus suffering was consistently the locus of conflict. These findings support the importance of tools such as the Serious Illness Conversation Guide that can be used by physicians to direct conversations on the patients’ goals, wishes, trade-offs, and to recommend a treatment plan that may include palliative care. Trial Registration Not applicable. (shrink)

In both the Phaedrus and Statesman dialogues, the dialectician's method of division is likened to the butchery of sacrificial animals. Interpreting the significance of this metaphor by analyzing ancient Greek sacrificial practice, this essay argues that, despite the ubiquity of the method of division in these later dialogues, Plato is there stressing the logical priority of the method of collection, division's dialectical twin. Although Plato prioritizes the method of collection, the author further argues that, through a kind of 'domestication' of (...) natural kinds, collection renders natural kinds knowable only by constructing them as implicitly divisible. As a result, the method of collection reflects not the wholeness of being but a constructed unity, the internal multiplicity of which makes possible each subsequent division. (shrink)

'This book is a masterpiece of theoretical thought. It anticipates the actual achievements of much of what we now call sociolinguistics.

Ellis argues that certain essential properties of objects in the world not only determine the nature of these objects but also how they will behave in any situation. In this paper I will critique Ellis's essentialism from the perspective of the philosophy of chemistry, arguing that our current knowledge of chemistry in fact does not lend itself to essentialist interpretations and that this seriously undercuts Ellis's project. In particular I will criticize two key distinctions Ellis draws between internal vs. external (...) properties and essential vs. accidental properties, showing that at the chemical level such distinctions are insupportable. If essential properties only exist at the level of sub-atomic physics, then Ellis's hopes that essentialism will provide a theoretical basis for a philosophy of chemistry are at best hopes for a very distant future, since the argument that chemical structure and dynamics can be explained at the quantum level derived is purely from analogy to much simpler systems than those chemists actually study. This suggests that we have very little scientific evidence that scientific essentialism is a viable ontology. †To contact the author, please write to: Department of Philosophy, University of Notre Dame, Notre Dame, IN 46556; e-mail: [email protected]. (shrink)

Despite Aristotle’s claim in Topics I that all dialectical argument is either syllogism or epagōgē, modern scholars have largely neglected to assess the role of epagōgē in Platonic dialectic. Though epagōgē has no technical use in Plato, I argue that the method of collection (which, along with division (diairēsis), is central to many of the dialogues’ accounts of dialectic) functions as the Platonic predecessor to Aristotelian epagōgē. An analysis of passages from the Sophist and Statesman suggests that collection is a (...) purificatory practice. I argue that collection is not only Plato’s account of generalization from a sensible many to an intelligible many, as suggested by the Phaedrus, but also functions as a method of diacritical selection that allows inquiry to move from the intelligible many produced by division to the intelligible unity of a definition. This reading contributes a deeper understanding of the mutual relationship of division and collection within Platonic dialectic as well as a way of unifying the accounts of dialectic in the Sophist and Statesman with the otherwise idiosyncratic account of dialectic in the Republic. Finally, this analysis of Platonic epagōgē sheds light on the connection between inquiry and argument present in Aristotle’s use of epagōgē. (shrink)